SPINK2 See also References Further reading Navigation menuPDBeRCSB2JXDSPINK277717SPINK2More reference expression datapeptidase inhibitor activityendopeptidase inhibitor activityprotein bindingserine-type endopeptidase inhibitor activityextracellular regionAcrosomeextracellular spacecytoplasmic vesicleregulation of acrosome reactionnegative regulation of peptidase activitynegative regulation of serine-type endopeptidase activityspermatogenesisacrosome assemblyspermatid developmentAmigoQuickGO6691ENSG00000128040P20155NM_001271718NM_001271719NM_001271720NM_001271721NM_001271722NM_021114NP_001258647NP_001258648NP_001258649NP_001258650NP_001258651NP_066937Chr 4: 56.81 – 56.82 MbGRCh38: Ensembl release 89: ENSG00000128040"Human PubMed Reference:"10.1016/0378-1119(93)90138-S8428671"Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)""The SPINK gene family and celiac disease susceptibility"10.1007/s00251-007-0199-5191423617333166"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"10.1101/gr.25965045289281548933410.1016/j.mrfmmm.2003.11.01715120973"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"10.1073/pnas.2426038991392411247793210.1016/0014-5793(90)81273-Q2226783180174310.1016/0014-5793(91)80099-O170431210.1515/bchm2.1976.357.2.1333791787expanding ite"Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes"10.1074/jbc.M111.244905319071821705336

Genes on human chromosome 4Human chromosome 4 gene stubs


6691ENSG00000128040P20155proteingene

































SPINK2


Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases
SPINK2, HUSI-II, serine peptidase inhibitor, Kazal type 2, SPGF29
External IDsHomoloGene: 77717 GeneCards: SPINK2








Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]

Chromosome 4 (human)
Genomic location for SPINK2

Genomic location for SPINK2

Band4q12Start56,809,860 bp[1]
End56,821,742 bp[1]

RNA expression pattern
PBB GE SPINK2 206310 at fs.png
More reference expression data






Orthologs
SpeciesHumanMouse
Entrez

6691

n/a

Ensembl

ENSG00000128040

n/a

UniProt

P20155

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 4: 56.81 – 56.82 Mbn/a

PubMed search		[2]n/a
Wikidata


View/Edit Human

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.[3][4]



See also


  • Kazal-type serine protease inhibitor domain


References




  1. ^ abc GRCh38: Ensembl release 89: ENSG00000128040 - Ensembl, May 2017


  2. ^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  3. ^ Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)". Gene. 123 (2): 277–81. doi:10.1016/0378-1119(93)90138-S. PMID 8428671.


  4. ^ "Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)".



[1]



Further reading


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Wapenaar MC, Monsuur AJ, Poell J, et al. (2007). "The SPINK gene family and celiac disease susceptibility". Immunogenetics. 59 (5): 349–57. doi:10.1007/s00251-007-0199-5. PMC 1914236. PMID 17333166.


  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


  • Rockett JC, Patrizio P, Schmid JE, et al. (2004). "Gene expression patterns associated with infertility in humans and rodent models". Mutat. Res. 549 (1–2): 225–40. doi:10.1016/j.mrfmmm.2003.11.017. PMID 15120973.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones". FEBS Lett. 270 (1–2): 222–4. doi:10.1016/0014-5793(90)81273-Q. PMID 2226783.


  • Collins J, Taube W, Fink E, et al. (1992). "Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase". Biomed. Biochim. Acta. 50 (4–6): 683–5. PMID 1801743.


  • Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II)". FEBS Lett. 278 (1): 127–30. doi:10.1016/0014-5793(91)80099-O. PMID 1704312.


  • Dietl T, Kruck J, Schill WB, Fritz H (1977). "Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique". Hoppe-Seyler's Z. Physiol. Chem. 357 (10): 1333–7. doi:10.1515/bchm2.1976.357.2.1333. PMID 791787.







  1. ^ Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C (2011). "Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes". J. Biol. Chem. 286 (33): 29108–17. doi:10.1074/jbc.M111.244905. PMC 3190718. PMID 21705336.







-

Popular posts from this blog

Thal And Out Agency railway station See also References External links Navigation menuOfficial Web Site of Pakistan RailwaysArchivedOfficial Web Site of Pakistan Railwayseeexpanding ite

Image
Golra Sharif KutbalFatehjangGaganChauntraKahal Basal Junction DomelNammalChura Sharif HaltLangar Jand Junction Khushalgarh Faqir Hussain ShaheedTilkanSeni GambatBabari BandaCadet College Kohat Kohat Cantonment Kohat Tehsil Nasrat Khel Chikarkot Ustarzai Raisan Ibrahimzai Hangu Doaba Darsmand Thal Aab-e-gumAhmedwalAlam RegAlozaiAzadBadinzaiBakhtiarabad DomkiBeleli Bostan Junction Chaman ChurmianDalbandinDamboliDera Allah YarDera Murad JamaliDingraDozanGalangurGatGulistanHirokKan MehtarzaiKhanaiKhan Muhammad ChahKila SaifullahKishingiKoh-e-TaftanKolpurKuchlakMachMangoliMirjavehMushkafMuslimbaghNok KundiNushkiNuttallPadag RoadPerakPehro KunriPanirPeshiQilla Abdullah Quetta Sar-i-AbSheikh MandahSheikh Wasil Sibi Junction Spezand Junction Shela BaghTozghiWali KhanYakmachYaru Zhob IslamabadGolra Sharif Junction Attock City Junction Attock KhurdBahawalpurChiniotDandot RSFaisalabadGujar KhanGujratJalloJhang SadarJhelum Khanewal Junction KhanpurKhewra Lahore Junction Lahore CantonmentLiaquat Pu...
Read more

Understanding generators in Python2019 Community Moderator ElectionGenerator function not working pythonFor loop not executing two timesGenerators - Printing generated valuesWhy can a python generator only be used once?What exactly do generators do?What does the “yield” keyword do?What does “list comprehension” mean? How does it work and how can I use it?sklearn Kfold acces single fold instead of for loopIs a generator the callable? Which is the generator?Apply Border To Range Of Cells Using OpenpyxlCalling an external command in PythonWhat are metaclasses in Python?What is the difference between @staticmethod and @classmethod?Finding the index of an item given a list containing it in PythonDifference between append vs. extend list methods in PythonHow can I safely create a nested directory in Python?Does Python have a ternary conditional operator?Understanding slice notationUnderstanding Python super() with __init__() methodsDoes Python have a string 'contains' substring method?

Image
What is it called when someone votes for an option that's not their first choice? Have the tides ever turned twice on any open problem? Is xar preinstalled on macOS? "Marked down as someone wanting to sell shares." What does that mean? Does fire aspect on a sword, destroy mob drops? Is VPN a layer 3 concept? Exposing a company lying about themselves in a tightly knit industry: Is my career at risk on the long run? Symbolism of 18 Journeyers How can a new country break out from a developed country without war? What is the difference between something being completely legal and being completely decriminalized? Does convergence of polynomials imply that of its coefficients? Friend wants my recommendation but I don't want to give it to him Why I don't get the wanted width of tcbox? Single word to change groups Would this string work as string? Unfrosted light bulb Air travel with refrigerated insulin What is the tangent at a sharp poi...
Read more

How can I change the color of pagination dots of UIPageControl?How to change UIPageControl dotsIs there a way to change page indicator dots colorCustomize dot with image of UIPageControl at index 0 of UIPageControlNo visible @interface for 'NSObject<PageControlDelegate>' declares the selector 'pageControlPageDidChange:'How to change the color of pagination dots in UIPageControl with a different color per pagepagecontrol indicator custom image instead of DefaultChanging the colour of UIPageControl dots in MonoTouchpagecontrol selectable page visibility color?Alternative way to load ViewControllers on a UIPageControlHow to set only layer.border-color for UIpage control dots in swiftHow can I develop for iPhone using a Windows development machine?How to change the name of an iOS app?UITableView - change section header coloruipagecontrol indicator(dot)issueCustom UIPageControl dots color not changingchange the interspace between UIPageControl dotsHow to change Status Bar text color in iOSHow can I change image tintColor in iOS and WatchKitUIPageControl dots with larger space in between each dotsHow to change the color of pagination dots in UIPageControl with a different color per page

Image
How do I implement a file system driver driver in Linux? Fly on a jet pack vs fly with a jet pack? Is possible to search in vim history? Translation of Scottish 16th century church stained glass Ridge Regression with Gradient Descent Converges to OLS estimates What linear sensor for a keyboard? Did US corporations pay demonstrators in the German demonstrations against article 13? Is it improper etiquette to ask your opponent what his/her rating is before the game? Why does Async/Await work properly when the loop is inside the async function and not the other way around? Why did the EU agree to delay the Brexit deadline? A Permanent Norse Presence in America Did arcade monitors have same pixel aspect ratio as TV sets? Can the Supreme Court overturn an impeachment? Drawing ramified coverings with tikz Greco-Roman egalitarianism Can someone explain how this makes sense electrically? Is it possible to use .desktop files to open local pdf files on specific pa...
Read more