Calcium channel opener See also References Navigation menu619603710.1016/j.ceca.2015.10.0022656068810.1016/j.ceca.2014.12.00525591931"Lysosomal Physiology"10.1146/annurev-physiol-021014-071649452456925668017eeexpanding ite

EnzymeInducerInhibitorIon channelOpenerBlockerReceptorAgonistPartial agonistAntagonistInverse agonistPositive allosteric modulatorNegative allosteric modulatorTransporterReuptakeEffluxEnhancerInhibitorReleaserPrecursorCofactorCalcium channel blockerPotassium channel blockerSodium channel blockerPotassium channel openerAdrenergic receptor agonistαβ12Adrenergic receptor antagonistα12βNorepinephrine reuptake inhibitorDopamine receptor agonistDopamine receptor antagonistDopamine reuptake inhibitorHistamine receptor agonistHistamine receptor antagonistH1H2H3Serotonin receptor agonistSerotonin receptor antagonist5-HT3Serotonin reuptake inhibitorGABA receptor agonistGABA receptor antagonistGABA reuptake inhibitorGlutamate receptor agonistAMPAGlutamate receptor antagonistNMDAGlutamate reuptake inhibitorAcetylcholine receptor agonistMuscarinicNicotinicAcetylcholine receptor antagonistMuscarinicNicotinicGanglionicMuscularCannabinoid receptor agonistCannabinoid receptor antagonistEndocannabinoid enhancerEndocannabinoid reuptake inhibitorOpioid modulatorOpioid receptor agonistOpioid receptor antagonistEnkephalinase inhibitorAdenosine reuptake inhibitorAngiotensin II receptor antagonistEndothelin receptor antagonistNK1 receptor antagonistVasopressin receptor antagonistCofactorEnzyme cofactorsPrecursorAmino acidsL-type-selectiveDihydropyridinesAmlodipineAranidipineAzelnidipineBarnidipineClevidipineCronidipineDarodipineDexniguldipineElgodipineElnadipineFelodipineFlordipineFurnidipineIganidipineIsradipineLacidipineLemildipineLercanidipineLevamlodipineLevniguldipineManidipineMepirodipineMesudipineNicardipineNifedipineNiguldipineNiludipineNilvadipineNimodipineNisoldipineNitrendipineOlradipineOxodipinePalonidipinePranidipineRyodipine (riodipine)SagandipineSornidipineTeludipineTiamdipineTrombodipineVatanidipineDiltiazemClentiazemDiltiazemIprotiazemNictiazemSiratiazemPhenylalkylaminesAnipamilDagapamilDevapamilDexverapamilEmopamilEtripamilFalipamilGallopamilLevemopamilNexopamilNorverapamilRonipamilTiapamilVerapamilAH-1058BrinazaroneBudiodaroneCelivaroneCyproheptadineDronedaroneFantofaroneSR-33805TetrahydropalmatineN-type-selectiveω-Conotoxinsω-Conotoxin GVIACaroverineHuwentoxin XVILeconotide (ω-conotoxin CVID)PD-173212RalfinamideSafinamideZ160Ziconotide (ω-conotoxin MVIIA)P-type-selectiveω-Agatoxin IVAω-Agatoxin IVBR-type-selectiveSNX-482T-type-selectiveABT-639ML-218Niflumic acidNNC 55-0396ProTx IZ944Zonisamideω-Agatoxin TKω-Conotoxin MVIICBenidipineBepridilCilnidipineCinnarizineDotarizineEfonidipineFlunarizineLamotrigineLevetiracetamLomerizineLoperamideMibefradilNP078585Ruthenium redTROX-1α2δ subunitgabapentinoids4-MethylpregabalinArbaclofenArbaclofen placarbilAtagabalinBaclofenGabapentinGabapentin enacarbilImagabalinMirogabalinPD-200,347PD-217,014PD-299,685PhenibutPregabalinBencyclaneBerbamineBevantololCanadineCarboxyamidotriazoleCycleanineDauricineDimeditiapramineDiproteverineEnpiperateEperisoneElpetrigineEthadioneEthanol (alcohol)EthosuximideFasudilFendilineFostedilImepitoinJTV-519LidoflazineMagnesiumManoalideMesuximideMonatepilNaftopidilOchratoxin AOstholOtilonium bromideParamethadionePhensuximidePinaverium bromidePrenylamineRhynchophyllineSesamodilSilperisoneSipatrigineTerodilineTetrandrineTolperisoneTrimethadioneValperinolL-type-selectiveBay K86443,4-Diaminopyridine (amifampridine)4-Aminopyridine (fampridine/dalfampridine)AdekalantAlmokalantAmiodaroneAzimilideBretyliumBunaftineCharybdotoxinClamikalantConotoxinsDalazatideDendrotoxinDofetilideDronedaroneE-4031HanatoxinHgeTx1HsTx1IbutilideInakalantKaliotoxinLinopirdineLolitrem BMaurotoxinNifekalantNotoxinPaxillinePinokalantQuinidineShK-186SotalolTedisamilTerikalantTetraethylammoniumVernakalanthERGAjmalineAmiodaroneAmmTX3AstemizoleAzaspiracidAZD1305AzimilideBedaquilineBeKm-1BmTx3BRL-32872ChlorpromazineCisaprideClarithromycinDarifenacinDextropropoxypheneDiallyl trisulfideDomperidoneE-4031ErgtoxinsErythromycinGigactonineHaloperidolKetoconazoleNorpropoxypheneOrphenadrinePimozidePNU-282,987PromethazineQuinidineRanolazineRoxithromycinSertindoleSolifenacinTamulotoxinTerodilineTerfenadineThioridazineTolterodineVanoxerineVernakalantKCNQ (Kv7)LinopirdineXE-991Spooky toxin (SsTx)KCNQ (Kv7)FlupirtineRetigabineKATPAcetohexamideCarbutamideChlorpropamideGlibenclamide (glyburide)GlibornurideGlicaramideGliclazideGlimepirideGlipizideGliquidoneGlisoxepideGlyclopyramideGlycyclamideMetahexamideMitiglinideNateglinideRepaglinideTolazamideTolbutamideGIRKBariumCaramiphenCloperastineClozapineDextromethorphanEthosuximideIfenprodilTertiapinTipepidineKATPAprikalimBimakalimCromakalimDiazoxideEmakalimLevcromakalimMazokalimMinoxidilNaminidilNicorandilPinacidilRilmakalimSarakalimGIRKML-297 (VU0456810)BKCaEthanol (alcohol)GAL-021BKCaFlufenamic acidMeclofenamic acidNiflumic acidNimesulideRottlerin (mallotoxin)Tolfenamic acid12-O-Tetradecanoylphorbol-13-acetateArachidonic acidFluoxetineNorfluoxetineRiluzoleRanolazineAjmalineAprindineDisopyramideDronedaroneEncainideFlecainideLidocaineLorajmineLorcainideMexiletineMoricizinePilsicainidePrajmalineProcainamidePropafenoneQuinidineSparteineTocainideAcetylpheneturideCarbamazepineCenobamateChlorphenacemideElpetrigineEslicarbazepine acetateEthotoinFosphenytoinLacosamideLicarbazepineMephenytoinOxcarbazepineOxitriptylinePhenacemidePheneturidePhenytoinRufinamideSipatrigineTopiramateSodium valproateValnoctamideValproate pivoxilValproate semisodiumValproic acidValpromideZonisamidepFBTAmylocaineArticaineBenzocaineBupivacaineLevobupivacaineRopivacaineButacaineButambenChloroprocaineCinchocaineCocaineCyclomethycaineDimethocaineDiphenhydramineEtidocaineHexylcaineIontocaineLidocaineMepivacaineMeprylcaineMetabutoxycaineOrthocainePiperocainePrilocaineProcainePropoxycaineProxymetacaineRisocaineTetracaineTrimecaineAZD-3161DSP-2230FunapideGDC-0276NKTR-171PF-04531083PF-05089771RalfinamideRaxatrigineRG7893 (GDC-0287)ConotoxinsNeosaxitoxinSaxitoxinTetrodotoxinZetekitoxin ABBuprenorphineEvenamideMentholmintSafinamideTricyclic antidepressantsAconitineAtracotoxinsRobustoxinVersutoxinBatrachotoxinCiguatoxinsGrayanotoxinsPoneratoxinAmilorideBenzamilTriamtereneSolnatideA-317567AmilorideAspirinIbuprofenPcTX1CrofelemerDIDSEthacrynic acidFlufenamic acidFluoxetineFurosemideGlibenclamideMefloquineMibefradilNiflumic acidCarbacholGlibenclamideLonidaminePiretanide1,7-Phenanthroline1,10-Phenanthroline4,7-Phenanthroline7,8-BenzoquinolineIvacaftorPhenanthridineBumetanideFlufenamic acidMeclofenamic acidMefenamic acidMepacrineNiflumic acidTalniflumateTolfenamic acidTrifluoperazinehere


Calcium channel openersPharmacology stubs


drugioncalcium channelsBay K8644analoguenifedipineL-typevoltage-dependent calcium channelsAmbroxol




A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels.


An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels.[1]


In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores.[2] This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type.[3][4]



See also


  • Calcium channel blocker


References




  1. ^ Schramm M, Thomas G, Towart R, Franckowiak G (1983). "Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants". Arzneimittelforschung. 33 (9): 1268–72. PMID 6196037..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  2. ^ Fois, Giorgio; Hobi, Nina; Felder, Edward; Ziegler, Andreas; Miklavc, Pika; Walther, Paul; Radermacher, Peter; Haller, Thomas; Dietl, Paul (2015). "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell Calcium. 58 (6): 628–637. doi:10.1016/j.ceca.2015.10.002. PMID 26560688.


  3. ^ Patel, Sandip; Cai, Xinjiang (2015). "Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels". Cell Calcium. 57 (3): 222–230. doi:10.1016/j.ceca.2014.12.005. PMID 25591931.


  4. ^ Xu, Haoxing; Ren, Dejian (2015-01-01). "Lysosomal Physiology". Annual Review of Physiology. 77 (1): 57–80. doi:10.1146/annurev-physiol-021014-071649. PMC 4524569. PMID 25668017.









-

Popular posts from this blog

Identity Server 4 is not redirecting to Angular app after login2019 Community Moderator ElectionIdentity Server 4 and dockerIdentityserver implicit flow unauthorized_clientIdentityServer Hybrid Flow - Access Token is null after user successful loginIdentity Server to MVC client : Page Redirect After loginLogin with Steam OpenId(oidc-client-js)Identity Server 4+.NET Core 2.0 + IdentityIdentityServer4 post-login redirect not working in Edge browserCall to IdentityServer4 generates System.NullReferenceException: Object reference not set to an instance of an objectIdentityServer4 without HTTPS not workingHow to get Authorization code from identity server without login form

Image
How to make healing in an exploration game interesting What's the meaning of “spike” in the context of “adrenaline spike”? Welcoming 2019 Pi day: How to draw the letter π? Do I need life insurance if I can cover my own funeral costs? What do Xenomorphs eat in the Alien series? Python if-else code style for reduced code for rounding floats My adviser wants to be the first author Do I need to get involved in office politics to get ahead? Why one should not leave fingerprints on bulbs and plugs? How to change two letters closest to a string and one letter immediately after a string using notepad++ Why doesn't the EU now just force the UK to choose between referendum and no-deal? How to deal with taxi scam when on vacation? Recruiter wants very extensive technical details about all of my previous work What is the least resource intensive way to generate the luatex font cache for a new font? How Could an Airship Be Repaired Mid-Flight ...
Read more

2005 Ahvaz unrest Contents Background Causes Casualties Aftermath See also References Navigation menue"At Least 10 Are Killed by Bombs in Iran""Iran"Archived"Arab-Iranians in Iran to make April 15 'Day of Fury'"State of Mind, State of Order: Reactions to Ethnic Unrest in the Islamic Republic of Iran.10.1111/j.1754-9469.2008.00028.x"Iran hangs Arab separatists"Iran Overview from ArchivedConstitution of the Islamic Republic of Iran"Tehran puzzled by forged 'riots' letter""Iran and its minorities: Down in the second class""Iran: Handling Of Ahvaz Unrest Could End With Televised Confessions""Bombings Rock Iran Ahead of Election""Five die in Iran ethnic clashes""Iran: Need for restraint as anniversary of unrest in Khuzestan approaches"Archived"Iranian Sunni protesters killed in clashes with security forces"Archived

Image
Sheikh Khazal (1924)Unrest (1925)Unrest (1928)Unrest (1940)1943 revolt1945 revoltInsurgency (1956-70)Insurgency (1979)Embassy siege (1980)Unrest (2005)2005–06 Ahvaz bombingsDay of Rage (2011)Uprising of Dignity (2018) Arab rebellionsProtests in Iran2005 riotsPolitical riots2005 in IranAhvazKhuzestan conflictHuman rights in IranAhwazi Arabs Iranian ArabsAhvazKhuzestanbombingsPersian GulfKhuzestanShadeganHoveyzehSusangerdMahshahrKhorramshahrAbadanAhvazConstitution of IranPersianofficial languageconstitution of the Islamic RepublicconstitutionIranian ArabsAmnesty InternationalConstitution of the Islamic Republic of IranMohammad-Ali AbtahiMohammad KhatamiAmnesty InternationalAli ShamkhaniAhvazIranian ArabsprotestAhvazNobel Peace PrizeShirin Ebadi 2005 Ahvaz unrest Part of Arab separatism in Khuzestan Iranian Khuzestan province Date 15–18 April 2005 Methods demonstrations, riots Status Unrest quelled Parties to the civil conflict Iranian Arabs Iranian Government Lead figures ...
Read more

Can't initialize raids on a new ASUS Prime B360M-A motherboard2019 Community Moderator ElectionSimilar to RAID config yet more like mirroring solution?Can't get motherboard serial numberWhy does the BIOS entry point start with a WBINVD instruction?UEFI performance Asus Maximus V Extreme

Image
"One can do his homework in the library" Why does Deadpool say "You're welcome, Canada," after shooting Ryan Reynolds in the end credits? Potential difference and current flow It's a yearly task, alright Co-worker team leader wants to inject the crap software product of his friends into our development. What should I say to our common boss? Touchscreen-controlled dentist office snowman collector game What to do when during a meeting client people start to fight (even physically) with each others? What options are left, if Britain cannot decide? How could our ancestors have domesticated a solitary predator? Professor being mistaken for a grad student When two POV characters meet Replacing Windows 7 security updates with anti-virus? What has been your most complicated TikZ drawing? Can the word "advantage" be used as an adjective? How could a female member of a species produce eggs unto death? Can the druid cantrip Thorn...
Read more