Calcium channel opener See also References Navigation menu619603710.1016/j.ceca.2015.10.0022656068810.1016/j.ceca.2014.12.00525591931"Lysosomal Physiology"10.1146/annurev-physiol-021014-071649452456925668017eeexpanding ite
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EnzymeInducerInhibitorIon channelOpenerBlockerReceptorAgonistPartial agonistAntagonistInverse agonistPositive allosteric modulatorNegative allosteric modulatorTransporterReuptakeEffluxEnhancerInhibitorReleaserPrecursorCofactorCalcium channel blockerPotassium channel blockerSodium channel blockerPotassium channel openerAdrenergic receptor agonistαβ12Adrenergic receptor antagonistα12βNorepinephrine reuptake inhibitorDopamine receptor agonistDopamine receptor antagonistDopamine reuptake inhibitorHistamine receptor agonistHistamine receptor antagonistH1H2H3Serotonin receptor agonistSerotonin receptor antagonist5-HT3Serotonin reuptake inhibitorGABA receptor agonistGABA receptor antagonistGABA reuptake inhibitorGlutamate receptor agonistAMPAGlutamate receptor antagonistNMDAGlutamate reuptake inhibitorAcetylcholine receptor agonistMuscarinicNicotinicAcetylcholine receptor antagonistMuscarinicNicotinicGanglionicMuscularCannabinoid receptor agonistCannabinoid receptor antagonistEndocannabinoid enhancerEndocannabinoid reuptake inhibitorOpioid modulatorOpioid receptor agonistOpioid receptor antagonistEnkephalinase inhibitorAdenosine reuptake inhibitorAngiotensin II receptor antagonistEndothelin receptor antagonistNK1 receptor antagonistVasopressin receptor antagonistCofactorEnzyme cofactorsPrecursorAmino acidsL-type-selectiveDihydropyridinesAmlodipineAranidipineAzelnidipineBarnidipineClevidipineCronidipineDarodipineDexniguldipineElgodipineElnadipineFelodipineFlordipineFurnidipineIganidipineIsradipineLacidipineLemildipineLercanidipineLevamlodipineLevniguldipineManidipineMepirodipineMesudipineNicardipineNifedipineNiguldipineNiludipineNilvadipineNimodipineNisoldipineNitrendipineOlradipineOxodipinePalonidipinePranidipineRyodipine (riodipine)SagandipineSornidipineTeludipineTiamdipineTrombodipineVatanidipineDiltiazemClentiazemDiltiazemIprotiazemNictiazemSiratiazemPhenylalkylaminesAnipamilDagapamilDevapamilDexverapamilEmopamilEtripamilFalipamilGallopamilLevemopamilNexopamilNorverapamilRonipamilTiapamilVerapamilAH-1058BrinazaroneBudiodaroneCelivaroneCyproheptadineDronedaroneFantofaroneSR-33805TetrahydropalmatineN-type-selectiveω-Conotoxinsω-Conotoxin GVIACaroverineHuwentoxin XVILeconotide (ω-conotoxin CVID)PD-173212RalfinamideSafinamideZ160Ziconotide (ω-conotoxin MVIIA)P-type-selectiveω-Agatoxin IVAω-Agatoxin IVBR-type-selectiveSNX-482T-type-selectiveABT-639ML-218Niflumic acidNNC 55-0396ProTx IZ944Zonisamideω-Agatoxin TKω-Conotoxin MVIICBenidipineBepridilCilnidipineCinnarizineDotarizineEfonidipineFlunarizineLamotrigineLevetiracetamLomerizineLoperamideMibefradilNP078585Ruthenium redTROX-1α2δ subunitgabapentinoids4-MethylpregabalinArbaclofenArbaclofen placarbilAtagabalinBaclofenGabapentinGabapentin enacarbilImagabalinMirogabalinPD-200,347PD-217,014PD-299,685PhenibutPregabalinBencyclaneBerbamineBevantololCanadineCarboxyamidotriazoleCycleanineDauricineDimeditiapramineDiproteverineEnpiperateEperisoneElpetrigineEthadioneEthanol (alcohol)EthosuximideFasudilFendilineFostedilImepitoinJTV-519LidoflazineMagnesiumManoalideMesuximideMonatepilNaftopidilOchratoxin AOstholOtilonium bromideParamethadionePhensuximidePinaverium bromidePrenylamineRhynchophyllineSesamodilSilperisoneSipatrigineTerodilineTetrandrineTolperisoneTrimethadioneValperinolL-type-selectiveBay K86443,4-Diaminopyridine (amifampridine)4-Aminopyridine (fampridine/dalfampridine)AdekalantAlmokalantAmiodaroneAzimilideBretyliumBunaftineCharybdotoxinClamikalantConotoxinsDalazatideDendrotoxinDofetilideDronedaroneE-4031HanatoxinHgeTx1HsTx1IbutilideInakalantKaliotoxinLinopirdineLolitrem 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(glyburide)GlibornurideGlicaramideGliclazideGlimepirideGlipizideGliquidoneGlisoxepideGlyclopyramideGlycyclamideMetahexamideMitiglinideNateglinideRepaglinideTolazamideTolbutamideGIRKBariumCaramiphenCloperastineClozapineDextromethorphanEthosuximideIfenprodilTertiapinTipepidineKATPAprikalimBimakalimCromakalimDiazoxideEmakalimLevcromakalimMazokalimMinoxidilNaminidilNicorandilPinacidilRilmakalimSarakalimGIRKML-297 (VU0456810)BKCaEthanol (alcohol)GAL-021BKCaFlufenamic acidMeclofenamic acidNiflumic acidNimesulideRottlerin (mallotoxin)Tolfenamic acid12-O-Tetradecanoylphorbol-13-acetateArachidonic acidFluoxetineNorfluoxetineRiluzoleRanolazineAjmalineAprindineDisopyramideDronedaroneEncainideFlecainideLidocaineLorajmineLorcainideMexiletineMoricizinePilsicainidePrajmalineProcainamidePropafenoneQuinidineSparteineTocainideAcetylpheneturideCarbamazepineCenobamateChlorphenacemideElpetrigineEslicarbazepine acetateEthotoinFosphenytoinLacosamideLicarbazepineMephenytoinOxcarbazepineOxitriptylinePhenacemidePheneturidePhenytoinRufinamideSipatrigineTopiramateSodium valproateValnoctamideValproate pivoxilValproate semisodiumValproic acidValpromideZonisamidepFBTAmylocaineArticaineBenzocaineBupivacaineLevobupivacaineRopivacaineButacaineButambenChloroprocaineCinchocaineCocaineCyclomethycaineDimethocaineDiphenhydramineEtidocaineHexylcaineIontocaineLidocaineMepivacaineMeprylcaineMetabutoxycaineOrthocainePiperocainePrilocaineProcainePropoxycaineProxymetacaineRisocaineTetracaineTrimecaineAZD-3161DSP-2230FunapideGDC-0276NKTR-171PF-04531083PF-05089771RalfinamideRaxatrigineRG7893 (GDC-0287)ConotoxinsNeosaxitoxinSaxitoxinTetrodotoxinZetekitoxin ABBuprenorphineEvenamideMentholmintSafinamideTricyclic antidepressantsAconitineAtracotoxinsRobustoxinVersutoxinBatrachotoxinCiguatoxinsGrayanotoxinsPoneratoxinAmilorideBenzamilTriamtereneSolnatideA-317567AmilorideAspirinIbuprofenPcTX1CrofelemerDIDSEthacrynic acidFlufenamic acidFluoxetineFurosemideGlibenclamideMefloquineMibefradilNiflumic acidCarbacholGlibenclamideLonidaminePiretanide1,7-Phenanthroline1,10-Phenanthroline4,7-Phenanthroline7,8-BenzoquinolineIvacaftorPhenanthridineBumetanideFlufenamic acidMeclofenamic acidMefenamic acidMepacrineNiflumic acidTalniflumateTolfenamic acidTrifluoperazinehere
Calcium channel openersPharmacology stubs
drugioncalcium channelsBay K8644analoguenifedipineL-typevoltage-dependent calcium channelsAmbroxol
A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels.
An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels.[1]
In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores.[2] This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type.[3][4]
See also
- Calcium channel blocker
References
^ Schramm M, Thomas G, Towart R, Franckowiak G (1983). "Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants". Arzneimittelforschung. 33 (9): 1268–72. PMID 6196037..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Fois, Giorgio; Hobi, Nina; Felder, Edward; Ziegler, Andreas; Miklavc, Pika; Walther, Paul; Radermacher, Peter; Haller, Thomas; Dietl, Paul (2015). "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell Calcium. 58 (6): 628–637. doi:10.1016/j.ceca.2015.10.002. PMID 26560688.
^ Patel, Sandip; Cai, Xinjiang (2015). "Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels". Cell Calcium. 57 (3): 222–230. doi:10.1016/j.ceca.2014.12.005. PMID 25591931.
^ Xu, Haoxing; Ren, Dejian (2015-01-01). "Lysosomal Physiology". Annual Review of Physiology. 77 (1): 57–80. doi:10.1146/annurev-physiol-021014-071649. PMC 4524569. PMID 25668017.
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