Insulin detemir Contents Medical use Side effects Chemistry Society and culture References External links Navigation menuMonographa606012by INNWHO169148-63-4DB013074FT78T86XVD04539(verify)"Insulin Detemir Monograph for Professionals""Insulin detemir Pregnancy and Breastfeeding Warnings""NADAC as of 2019-02-27""The Top 300 of 2019"http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm166358.htmInsulin detemir DailyMedee

BuforminMetforminPhenforminCiglitazoneDarglitazoneEnglitazoneLobeglitazoneNetoglitazonePioglitazoneRivoglitazoneRosiglitazoneTroglitazoneAleglitazarMuraglitazarSaroglitazarTesaglitazarAcetohexamideCarbutamideChlorpropamideGlycyclamideMetahexamideTolazamideTolbutamideGlibenclamide (glyburide)GlibornurideGlicaramideGliclazideGlimepirideGlipizideGliquidoneGlisoxepideGlyclopyramideMitiglinideNateglinideRepaglinideAlbiglutideDulaglutideExenatideLiraglutideLixisenatideSemaglutideTaspoglutideAlogliptinAnagliptinEvogliptinGarvagliptinGemigliptinGosogliptinLinagliptinMelogliptinOmarigliptinSaxagliptinSitagliptinTeneligliptinTrelagliptinVildagliptinFasiglifamInsulin aspartInsulin glulisineInsulin lisproRegular insulinInsulin detemirInsulin glargineNPH insulinInsulin degludecExuberaAfrezzaEpalrestatFidarestatRanirestatTolrestatZenarestatAcarboseMiglitolVoglibosePramlintideCanagliflozinDapagliflozinEmpagliflozinIpragliflozinRemogliflozinSergliflozinTofogliflozinBenfluorexBromocriptineWHO-EMWithdrawnClinical trialsPhase III


Insulin receptor agonistsInsulin therapies


insulindiabetes mellitus type 1type 2injection under the skinlow blood sugarallergic reactionspregnancybreastfeedingglucoseNHSdiabetes mellitus type 1type 2NPH insulininsulin glarginelow blood sugarallergic reactionspregnancybreastfeedingfatty acidmyristic acidlysinealbuminU.S. Food and Drug Administration






































Insulin detemir, sold under the brand name Levemir among others, is a long-acting insulin used to treat diabetes mellitus type 1 and type 2.[1] It is used by injection under the skin.[1] It is effective for up to 24 hours.[1]


Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.[1] Use in pregnancy and breastfeeding appears safe.[2] It works by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver.[1]


Insulin detemir was approved for medical use in the United States in 2005.[1] In the United Kingdom it costs the NHS about 2.80 £ per 100 units as of 2019.[3] In the United States the wholesale cost of this amount is about 29.50 USD.[4] In 2016 it was the 121st most prescribed medication in the United States with more than 6 million prescriptions.[5]




Contents





  • 1 Medical use


  • 2 Side effects


  • 3 Chemistry


  • 4 Society and culture


  • 5 References


  • 6 External links




Medical use


It is used to treat diabetes mellitus type 1 and type 2.[1] With respect to blood sugar management, it appears to work at least as well as NPH insulin and insulin glargine.[1]



Side effects


Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.[1] Use in pregnancy and breastfeeding appears safe.[2]



Chemistry


It is an insulin analogue in which a fatty acid (myristic acid) is bound to the lysine amino acid at position B29. It is quickly absorbed after which it binds to albumin in the blood through its fatty acid at position B29. It then slowly dissociates from this complex.



Society and culture


On June 13, 2009, the U.S. Food and Drug Administration (FDA) issued a public health advisory for insulin determir after learning that 129,000 stolen vials reappeared and were being sold in the U.S. market. The FDA warned that the stolen vials "may not have been stored and handled properly and may be dangerous for patients to use." The stolen vials were identified as lots XZF0036, XZF0037, and XZF0038.[6]



References




  1. ^ abcdefghi "Insulin Detemir Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  2. ^ ab "Insulin detemir Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.


  3. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 701. ISBN 9780857113382.


  4. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.


  5. ^ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.


  6. ^ http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm166358.htm. Retrieved 9 March 2019. Missing or empty |title= (help)




External links


  • Insulin detemir DailyMed
Insulin detemir
Clinical data
Trade namesLevemir

AHFS/Drugs.com
Monograph
MedlinePlusa606012
License data


  • EU EMA: by INN

Pregnancy
category


  • US: B (No risk in non-human studies)

Routes of
administration		Subcutaneous
ATC code

  • A10AE05 (WHO)
Legal status
Legal status


  • US: ℞-only


Pharmacokinetic data
Bioavailability60% (when administered s.c.)
Elimination half-life
5–7 hours
Identifiers
CAS Number

  • 169148-63-4 ☒N
DrugBank

  • DB01307 ☑Y
ChemSpider
  • none
UNII
  • 4FT78T86XV
KEGG

  • D04539 ☑Y
Chemical and physical data
Formula
C267H402N64O76S6
Molar mass5913 g/mol g·mol−1

.mw-parser-output .noboldfont-weight:normal
 ☒N☑Y (what is this?)
  (verify)












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