Hypokalemic sensory overstimulation Contents Cause Diagnosis Treatment References Navigation menu10.1177/088307380730709518174562"We Cannot Say Whether Attention Deficit Hyperactivity Disorder Exists, but We Can Find its Molecular Mechanisms"10.1016/j.pediatrneurol.2014.04.01424938135NCT03563573"What causes ADHD? Some intriguing findings""Practical aspects in the management of hypokalemic periodic paralysis"10.1186/1479-5876-6-18237476818426576ee

MeningesSpinal cordBrainHindbrainMedullaPonsCerebellumMidbrainForebrainDiencephalonRetinaOptic nerveCerebrumLimbic systemSensory nerveMotor nerveCranial nerveSpinal nerveSympatheticParasympatheticEntericGeneralSedationTwilight anesthesiaLocalTopicalIntercostal nerve blockNeuraxial blockadeSpinalEpiduralDentalInferior alveolar nerveBlood–gas partition coefficientConcentration effectFink effectMinimum alveolar concentrationSecond gas effectAnaesthetic machineAnesthesia cartBoyle's machineGas cylinderLaryngeal mask airwayLaryngeal tubeMedical monitorOdom's indicatorRelative analgesia machineVaporiserDouble-lumen endotracheal tubeEndobronchial blockerCardiothoracicCritical emergency medicineGeriatricIntensive care medicineObstetricOral sedation dentistryPain medicineA.C.E. mixtureHelsinki Declaration for Patient Safety in AnaesthesiologyHistory of general anesthesiaHistory of neuraxial anesthesiaHistory of tracheal intubation


PainNeurological disordersDentistryAnesthesiaAttention deficit hyperactivity disorderPsychiatric diagnosisLocal anestheticsSodium channel blockers


lidocaineADHDhot tooth syndromehypokalemic periodic paralysispremenstrual syndromehypokalemic periodic paralysislidocainearticaine




Hypokalemic sensory overstimulation

Hypokalemic sensory overstimulation is characterized by a subjective experience of sensory overload and a relative resistance to lidocaine local anesthesia. The sensory overload is treatable with oral potassium gluconate. Individuals with this condition are sometimes diagnosed as having attention deficit hyperactivity disorder (ADHD), raising the possibility that a subtype of ADHD has a cause that can be understood mechanistically and treated in a novel way.


It is not to be confused with hot tooth syndrome.




Contents





  • 1 Cause


  • 2 Diagnosis


  • 3 Treatment


  • 4 References




Cause


Hypokalemic sensory overstimulation is a term coined by MM Segal and colleagues to describe a syndrome of sensory overstimulation, ineffectiveness of the local anesthetic lidocaine, and in females, premenstrual syndrome.[1] This initial report was followed by discussion in a second article of tens of families with apparent autosomal dominant inheritance of this condition.[2] The similarities were described clinically to ADHD and mechanistically and therapeutically to disorders of ion channels, in particular to the muscle disorder hypokalemic periodic paralysis. Some females with premenstrual syndrome may have the same autosomal dominant disorder underlying their symptoms.[2]



Diagnosis


A test for lidocaine ineffectiveness was briefly described in the 2014 paper[2] but the controlled trial has not yet been completed.[3]



Treatment


The use of oral potassium and avoiding high carbohydrate meals can help treat it according to recent tests, following the same approach that is standard for the muscle disease hypokalemic periodic paralysis.[4][5]


Since this condition includes ineffectiveness of the sodium-channel blocker lidocaine, the amide-type local anesthetic used in dental care articaine was tested and found to be effective in one member of the family.[1] No data about other local anesthetics effective in these individuals for non-dental procedures has yet been published.



References




  1. ^ ab Segal, M. M; Rogers, G. F; Needleman, H. L; Chapman, C. A (2007). "Hypokalemic sensory overstimulation". Journal of Child Neurology. 22 (12): 1408–10. doi:10.1177/0883073807307095. PMID 18174562..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  2. ^ abc Segal, Michael M (2014). "We Cannot Say Whether Attention Deficit Hyperactivity Disorder Exists, but We Can Find its Molecular Mechanisms". Pediatric Neurology. 51 (1): 15–16. doi:10.1016/j.pediatrneurol.2014.04.014. PMID 24938135.


  3. ^ Clinical trial number NCT03563573 for "Single-dose Potassium Supplementation in Patients With ADHD for Whom the Anesthetic Lidocaine is Ineffective" at ClinicalTrials.gov


  4. ^ "What causes ADHD? Some intriguing findings". 11 January 2008.


  5. ^ Levitt, Jacob O. (21 April 2008). "Practical aspects in the management of hypokalemic periodic paralysis". Journal of Translational Medicine. 6 (1): 18. doi:10.1186/1479-5876-6-18. PMC 2374768. PMID 18426576.













-

Popular posts from this blog

Can't initialize raids on a new ASUS Prime B360M-A motherboard2019 Community Moderator ElectionSimilar to RAID config yet more like mirroring solution?Can't get motherboard serial numberWhy does the BIOS entry point start with a WBINVD instruction?UEFI performance Asus Maximus V Extreme

Image
"One can do his homework in the library" Why does Deadpool say "You're welcome, Canada," after shooting Ryan Reynolds in the end credits? Potential difference and current flow It's a yearly task, alright Co-worker team leader wants to inject the crap software product of his friends into our development. What should I say to our common boss? Touchscreen-controlled dentist office snowman collector game What to do when during a meeting client people start to fight (even physically) with each others? What options are left, if Britain cannot decide? How could our ancestors have domesticated a solitary predator? Professor being mistaken for a grad student When two POV characters meet Replacing Windows 7 security updates with anti-virus? What has been your most complicated TikZ drawing? Can the word "advantage" be used as an adjective? How could a female member of a species produce eggs unto death? Can the druid cantrip Thorn
Read more

Identity Server 4 is not redirecting to Angular app after login2019 Community Moderator ElectionIdentity Server 4 and dockerIdentityserver implicit flow unauthorized_clientIdentityServer Hybrid Flow - Access Token is null after user successful loginIdentity Server to MVC client : Page Redirect After loginLogin with Steam OpenId(oidc-client-js)Identity Server 4+.NET Core 2.0 + IdentityIdentityServer4 post-login redirect not working in Edge browserCall to IdentityServer4 generates System.NullReferenceException: Object reference not set to an instance of an objectIdentityServer4 without HTTPS not workingHow to get Authorization code from identity server without login form

Image
How to make healing in an exploration game interesting What's the meaning of “spike” in the context of “adrenaline spike”? Welcoming 2019 Pi day: How to draw the letter π? Do I need life insurance if I can cover my own funeral costs? What do Xenomorphs eat in the Alien series? Python if-else code style for reduced code for rounding floats My adviser wants to be the first author Do I need to get involved in office politics to get ahead? Why one should not leave fingerprints on bulbs and plugs? How to change two letters closest to a string and one letter immediately after a string using notepad++ Why doesn't the EU now just force the UK to choose between referendum and no-deal? How to deal with taxi scam when on vacation? Recruiter wants very extensive technical details about all of my previous work What is the least resource intensive way to generate the luatex font cache for a new font? How Could an Airship Be Repaired Mid-Flight Why did it take so
Read more

2005 Ahvaz unrest Contents Background Causes Casualties Aftermath See also References Navigation menue"At Least 10 Are Killed by Bombs in Iran""Iran"Archived"Arab-Iranians in Iran to make April 15 'Day of Fury'"State of Mind, State of Order: Reactions to Ethnic Unrest in the Islamic Republic of Iran.10.1111/j.1754-9469.2008.00028.x"Iran hangs Arab separatists"Iran Overview from ArchivedConstitution of the Islamic Republic of Iran"Tehran puzzled by forged 'riots' letter""Iran and its minorities: Down in the second class""Iran: Handling Of Ahvaz Unrest Could End With Televised Confessions""Bombings Rock Iran Ahead of Election""Five die in Iran ethnic clashes""Iran: Need for restraint as anniversary of unrest in Khuzestan approaches"Archived"Iranian Sunni protesters killed in clashes with security forces"Archived

Image
Sheikh Khazal (1924)Unrest (1925)Unrest (1928)Unrest (1940)1943 revolt1945 revoltInsurgency (1956-70)Insurgency (1979)Embassy siege (1980)Unrest (2005)2005–06 Ahvaz bombingsDay of Rage (2011)Uprising of Dignity (2018) Arab rebellionsProtests in Iran2005 riotsPolitical riots2005 in IranAhvazKhuzestan conflictHuman rights in IranAhwazi Arabs Iranian ArabsAhvazKhuzestanbombingsPersian GulfKhuzestanShadeganHoveyzehSusangerdMahshahrKhorramshahrAbadanAhvazConstitution of IranPersianofficial languageconstitution of the Islamic RepublicconstitutionIranian ArabsAmnesty InternationalConstitution of the Islamic Republic of IranMohammad-Ali AbtahiMohammad KhatamiAmnesty InternationalAli ShamkhaniAhvazIranian ArabsprotestAhvazNobel Peace PrizeShirin Ebadi 2005 Ahvaz unrest Part of Arab separatism in Khuzestan Iranian Khuzestan province Date 15–18 April 2005 Methods demonstrations, riots Status Unrest quelled Parties to the civil conflict Iranian Arabs Iranian Government Lead figures Ali Khamen
Read more