Hypokalemic sensory overstimulation Contents Cause Diagnosis Treatment References Navigation menu10.1177/088307380730709518174562"We Cannot Say Whether Attention Deficit Hyperactivity Disorder Exists, but We Can Find its Molecular Mechanisms"10.1016/j.pediatrneurol.2014.04.01424938135NCT03563573"What causes ADHD? Some intriguing findings""Practical aspects in the management of hypokalemic periodic paralysis"10.1186/1479-5876-6-18237476818426576ee

MeningesSpinal cordBrainHindbrainMedullaPonsCerebellumMidbrainForebrainDiencephalonRetinaOptic nerveCerebrumLimbic systemSensory nerveMotor nerveCranial nerveSpinal nerveSympatheticParasympatheticEntericGeneralSedationTwilight anesthesiaLocalTopicalIntercostal nerve blockNeuraxial blockadeSpinalEpiduralDentalInferior alveolar nerveBlood–gas partition coefficientConcentration effectFink effectMinimum alveolar concentrationSecond gas effectAnaesthetic machineAnesthesia cartBoyle's machineGas cylinderLaryngeal mask airwayLaryngeal tubeMedical monitorOdom's indicatorRelative analgesia machineVaporiserDouble-lumen endotracheal tubeEndobronchial blockerCardiothoracicCritical emergency medicineGeriatricIntensive care medicineObstetricOral sedation dentistryPain medicineA.C.E. mixtureHelsinki Declaration for Patient Safety in AnaesthesiologyHistory of general anesthesiaHistory of neuraxial anesthesiaHistory of tracheal intubation


PainNeurological disordersDentistryAnesthesiaAttention deficit hyperactivity disorderPsychiatric diagnosisLocal anestheticsSodium channel blockers


lidocaineADHDhot tooth syndromehypokalemic periodic paralysispremenstrual syndromehypokalemic periodic paralysislidocainearticaine




Hypokalemic sensory overstimulation

Hypokalemic sensory overstimulation is characterized by a subjective experience of sensory overload and a relative resistance to lidocaine local anesthesia. The sensory overload is treatable with oral potassium gluconate. Individuals with this condition are sometimes diagnosed as having attention deficit hyperactivity disorder (ADHD), raising the possibility that a subtype of ADHD has a cause that can be understood mechanistically and treated in a novel way.


It is not to be confused with hot tooth syndrome.




Contents





  • 1 Cause


  • 2 Diagnosis


  • 3 Treatment


  • 4 References




Cause


Hypokalemic sensory overstimulation is a term coined by MM Segal and colleagues to describe a syndrome of sensory overstimulation, ineffectiveness of the local anesthetic lidocaine, and in females, premenstrual syndrome.[1] This initial report was followed by discussion in a second article of tens of families with apparent autosomal dominant inheritance of this condition.[2] The similarities were described clinically to ADHD and mechanistically and therapeutically to disorders of ion channels, in particular to the muscle disorder hypokalemic periodic paralysis. Some females with premenstrual syndrome may have the same autosomal dominant disorder underlying their symptoms.[2]



Diagnosis


A test for lidocaine ineffectiveness was briefly described in the 2014 paper[2] but the controlled trial has not yet been completed.[3]



Treatment


The use of oral potassium and avoiding high carbohydrate meals can help treat it according to recent tests, following the same approach that is standard for the muscle disease hypokalemic periodic paralysis.[4][5]


Since this condition includes ineffectiveness of the sodium-channel blocker lidocaine, the amide-type local anesthetic used in dental care articaine was tested and found to be effective in one member of the family.[1] No data about other local anesthetics effective in these individuals for non-dental procedures has yet been published.



References




  1. ^ ab Segal, M. M; Rogers, G. F; Needleman, H. L; Chapman, C. A (2007). "Hypokalemic sensory overstimulation". Journal of Child Neurology. 22 (12): 1408–10. doi:10.1177/0883073807307095. PMID 18174562..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  2. ^ abc Segal, Michael M (2014). "We Cannot Say Whether Attention Deficit Hyperactivity Disorder Exists, but We Can Find its Molecular Mechanisms". Pediatric Neurology. 51 (1): 15–16. doi:10.1016/j.pediatrneurol.2014.04.014. PMID 24938135.


  3. ^ Clinical trial number NCT03563573 for "Single-dose Potassium Supplementation in Patients With ADHD for Whom the Anesthetic Lidocaine is Ineffective" at ClinicalTrials.gov


  4. ^ "What causes ADHD? Some intriguing findings". 11 January 2008.


  5. ^ Levitt, Jacob O. (21 April 2008). "Practical aspects in the management of hypokalemic periodic paralysis". Journal of Translational Medicine. 6 (1): 18. doi:10.1186/1479-5876-6-18. PMC 2374768. PMID 18426576.













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