SDCCAG8 Contents
Clinical significance
Interactions
References
Further reading
Navigation menuSDCCAG819240664839SDCCAG8protein bindingcytoplasmcytosolcell junctioncentriolar satellitecytoskeletoncell-cell junctioncentrosomecentrioleneuron migrationG2/M transition of mitotic cell cyclemicrotubule organizing center organizationestablishment of cell polaritytube formationciliary basal body dockingcentrosome cycleregulation of G2/M transition of mitotic cell cycleAmigoQuickGO1080676816ENSG00000054282ENSG00000276111ENSMUSG00000026504Q86SQ7Q80UF4NM_006642NM_001350246NM_001350247NM_001350248NM_001350249NM_001350251NM_029756NM_001357390NP_006633NP_001337175NP_001337176NP_001337177NP_001337178NP_001337180NP_084032NP_001344319Chr 1: 243.26 – 243.5 MbChr 1: 176.81 – 177.02 MbENSG00000276111 GRCh38: Ensembl release 89: ENSG00000054282, ENSG00000276111GRCm38: Ensembl release 89: ENSMUSG00000026504"Human PubMed Reference:""Mouse PubMed Reference:"10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P9610721"Entrez Gene: SDCCAG8 serologically defined colon cancer antigen 8""Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy"10.1038/ng.662294762020835237"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"10.1101/gr.25965045289281548933410.1038/nbt9711514619710.1038/ng12851470203910.1038/nature021661465484310.1016/S0378-1119(02)01141-112559564"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"10.1073/pnas.24260389913924112477932"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"10.1101/gr.14020031093411042152eexpanding ite
Genes on human chromosome 1Human chromosome 1 gene stubs
Serologically defined colon cancer antigen 8 is a protein that in humans is encoded by the SDCCAG8 gene.[5][6] This protein localizes to the centrioles.[7]
Contents
1Clinical significance
2Interactions
3References
4Further reading
Clinical significance
Mutations in SDCCAG8 have been found to cause nephronophthisis-related ciliopathies.[7]
Interactions
SDCCAG8 has been shown to interact directly with OFD1, a protein that is also associated with nephronophthisis-related ciliopathies.[7]
^Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
^"Entrez Gene: SDCCAG8 serologically defined colon cancer antigen 8".
^ abcOtto EA, Hurd TW, Airik R, et al. (October 2010). "Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy". Nat. Genet. 42 (10): 840–50. doi:10.1038/ng.662. PMC 2947620. PMID 20835237.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
Kenedy AA, Cohen KJ, Loveys DA, et al. (2003). "Identification and characterization of the novel centrosome-associated protein CCCAP". Gene. 303: 35–46. doi:10.1016/S0378-1119(02)01141-1. PMID 12559564.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
v
t
e
Ciliary proteins
Nephrocystin
NPHP1
INVS
NPHP3
NPHP4
IQCB1
CEP290
GLIS2
RPGRIP1L
Basal body
BBsome
BBS1
BBS2
BBS4
BBS5
BBS7
TTC8
BBS9
chaperone
MKKS
BBS10
BBS12
Other
ARL6
TRIM32
ALMS1
CC2D2A
CEP290
MKS1
RPGRIP1L
OFD1
AHI1
INVS
NPHP4
NEK8
NPHP1
Cilia
connecting cilia
LCA5
RP1
RPGR
RPGRIP1
TULP1
primary cilia
ARL13B
INPP5E
IQCB1
PKHD1
PKD1
PKD2
TMEM67
Dynein
outer dynein arms
DNAH5
DNAI2
DNAL1
axoneme
DNAH11
DNAI1
Radial spokes
RSPH1
RSPH3
RSPH4A
RSPH6A
RSPH9
RSPH10B
Other
cytoplasm
KTU
nucleus
GLIS2
intraflagellar transport
IFT80
other
AHI1
ARL13B
BRCC3
INPP5E
KIF3A
LRRC50
SDCCAG8
TMEM216
TXNDC3
see also: ciliopathy
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
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